Endocrine Abstracts

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Introduction: Graves’ disease is an autoimmune disorder of the thyroid gland causing over-production of thyroid hormone. Although this disorder can lead to systemic changes throughout the body, the most common extrathyroid manifestation of Graves’ disease is ophthalmopathy. Patients can have significant ocular prominence from the increase in intraconal and extraconal fat and muscular hypertrophy. This can lead to vision changes, decreased ocular motilit...

Introduction: Graves’ disease is an autoimmune disorder of the thyroid gland causing over-production of thyroid hormone. Although this disorder can lead to systemic changes throughout the body, the most common extrathyroid manifestation of Graves’ disease is ophthalmopathy. Patients can have significant ocular prominence from the increase in intraconal and extraconal fat and muscular hypertrophy. This can lead to vision changes, decreased ocular motilit...

Background: Intranasal steroids are commonly used for allergic rhinitis, rhinosinusitis and nasal polyps as they are considered safe in terms of long-term adverse effects profile due to favourable pharmacokinetic characteristics as compared to other oral and inhaled steroids. Some are also available over the counter without prescription.Case: We report a patient with iatrogenic Cushing”s syndrome and secondary adrenal insufficiency due to chronic in...

Hyponatremia due to water intoxication is often associated with mental disorders like schizophrenia and psychosis. Patients usually present with headaches, seizures and altered consciousness. The mainstay treatment in these cases is fluid restriction. A 31-year-old man was brought to the hospital following a fall and disorientation. He had a history of Schizophrenia which had been well controlled on risperidone. A few weeks before this presentation, he drank about 20 litres of...

Background: Glucose metabolism derangements (GMD) and thyroid nodules (TN) are the most frequent endocrine disorders. A relationship between these conditions has been suggested, but data are still controversial and no evidence was reported regarding sex differences.Aim: To evaluate the distribution of impaired fasting glucose (IFG), normal glucose tolerance (NGT), impaired glucose tolerance (IGT), type 2 diabetes (T2DM) and TN according to sex.<p cla...

BackgroundPapillary thyroid carcinoma (PTC) is the most frequent thyroid malignant neoplasm. American Thyroid Association (ATA) guidelines don’t specify how to follow-up low-risk PTC patients not receiving radioiodine therapy (RAI) after total thyroidectomy (TT). Indeed, there is no consensus among authors regarding the interpretation of thyroglobulin (TG) levels and ultrasound neck (US) findings during follow-up in these settings.<p class="abst...

Introduction: Accurately discern malignant from benign nodules sometimes represents a real challenge. Fine needle aspiration (FNA) biopsy, ultrasound and The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) allow for accurate diagnosis in 60–80% of all nodules. However, 10–20% of thyroid FNAs yield an indeterminate cytology (BSRTC III and IV categories). The real malignancy rate of BSRTC III category is difficult to ascertain because histopathological anal...

We recently showed that 5α-reduced metabolites of corticosterone (B), namely 5α-dihydrocorticosterone (5αDHB) and 5α-tetrahydrocorticosterone (5αTHB), possess similar anti-inflammatory properties to B, but have lesser metabolic effects. Here, we explored the anti-inflammatory mechanisms of these 5α-reduced metabolites in vitro. Data are mean % suppression/induction, compared by one way ANOVA, *P<0.05 versus vehicle.<p class="...

Previously, we have described an inhibitory role of melatonin (Mel) in the expression of StAR and key steroidogenic enzymes, as well as in the regulation of testosterone production in testes of Syrian hamsters. The goal of the present work was to further investigate the signaling pathway involves in the testicular action of Mel. Thus, Leydig cells were purified from reproductively active hamsters killed by asphyxia with carbon dioxide, and incubated in the presence of Mel and ...